What is hereditary angioedema (HAE)?

HAE is a rare, chronic genetic condition that involves recurring, unpredictable, severe, and potentially life-threatening swelling attacks. That's why finding a treatment that can give you lasting control is important.

While everyone’s experience with HAE is different, you may recognize some similarities in what others have shared.

 

HAE can impact everyday life for you and your family

Because HAE is genetic, it may affect multiple members of the same family. For most, it starts early, and it has been reported that approximately half of people experiencing their first attack before 10 years of age.

These ongoing, unpredictable swelling attacks can lead to missing out again and again. In fact, almost 3 in 4 of people with HAE reported that they make trade-offs in their lives due to the unpredictability of attacks.* 

ALMOST

9 out of 10

people reported that they frequently missed or avoided events because of their HAE*

hae-attack

of people reported an HAE attack in the past year, but doctors estimated only 64%, highlighting a gap in awareness* 

ALMOST

two-thirds

of people reported they felt that they still hadn’t found the best preventative treatment for them*

*Online survey conducted by The Harris Poll of 150 US adults diagnosed with HAE by a health care provider and 228 board-certified allergists and immunologists practicing in the US, sponsored by Ionis.

I’ve had HAE since I was 2. Stress was definitely my biggest trigger. I missed a lot of school growing up, I’ve had to change my job, I felt like I’ve always had to constantly explain myself.”
Michael, an individual with HAE

An actual DAWNZERA patient. Patient was compensated for their time.

Image of AECT test Image of AECT test

Test your disease control

If you’re unsure whether your HAE is under control, the Angioedema Control Test (AECT) can help. The AECT is a
4-question test that can help you and your doctor determine if you’re well controlled or poorly controlled.

Take the test

IMPORTANT SAFETY INFORMATION & INDICATION

Do not use DAWNZERA if you have had a serious allergic reaction, including anaphylaxis to donidalorsen or any of the ingredients in DAWNZERA.  

Before using DAWNZERA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. It is not known if DAWNZERA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby. 

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.  

What are the possible side effects of DAWNZERA?

DAWNZERA can cause serious side effects including allergic reactions. Allergic reactions can include rash, trouble breathing, chest pain, fainting, dizziness, feeling lightheaded, swelling of the face, lips or tongue, and itching. Stop using DAWNZERA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

The most common side effects of DAWNZERA include injection site reactions (such as redness or pain at the injection site), upper respiratory tract infection, urinary tract infection, abdominal discomfort.

These are not all the possible side effects of DAWNZERA. Tell your healthcare provider or treatment team about any side effects you may have. 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.  

INDICATION

DAWNZERA™ (donidalorsen) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12  years of age and older. 

It is not known if DAWNZERA is safe and effective in children under 12 years of age. 

Please see full Prescribing Information and Patient Information for DAWNZERA.